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What are the factors that affect the degradation of degradable materials

View:273 2021-04-23

Degradable materials generally referred to in biomaterials refer to materials that can be completely                   degraded in the body, and the degradation products can be absorbed and metabolized by the body. The degradation referred to here reflects a universal characteristic of materials or devices in the human body, not for a certain type of material. The degradation concept involved here includes not only the mechanical abrasion between the various parts of the device, but also the cracking or corrosion of the material structure due to the interaction between the living body and the material. The latter is also called biodegradation.

       It can be seen that the degradation products may be the fragments and pyrolysis products of the granular host material produced by mechanical abrasion, or the free ions released from the surface of the material due to biodegradation or the chemical structure of the host material is different. Of organic or inorganic compounds.

There are many factors that affect the degradation of degradable materials, mainly from two aspects: the external environment and the internal composition of the material:
1. The external environment,
The external environment includes specific conditions such as temperature, pH, soil compost, and biological enzymes, or in the natural environment. In the experiment, heating is a way to shorten the experiment cycle, while a too low temperature may not achieve the desired degradation effect, so To reduce the influence of temperature, air flow, and biological enzymes on degradable materials, fully degradable materials should be stored in a cool and dry environment.
2. Internal environment,
In terms of the composition of the fully degradable material, it is simply the influence of the material structure, the hydrophilicity/hydrophobicity of the polymer, the monomer composition ratio and the molecular weight on the degradation. The structure of a material with a fast degradation rate, or a polymer with strong hydrophilicity, sufficient contact surface between the internal molecules of the material and the water molecule, and the polymer can be hydrolyzed in many parts, the degradation rate is fast, and vice versa.

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